Publications

Tang T, Tan Q, Han S, Diemar A, Löbner K, Wang H, Schüß C, Behr V, Mörl K, Wang M, Chu X, Yi C, Keller M, Kofoed J, Reedtz-Runge S, Kaiser A, Beck-Sickinger AG, Zhao Q, Wu B. Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors. Sci Adv. 2022; 8(18):eabm1232. doi: 10.1126/sciadv.abm1232. 

Groß VE, Gershkovich MM, Schöneberg T, Kaiser A, Prömel S. NanoBRET in C. elegans illuminates functional receptor interactions in real time. BMC Mol Cell Biol. 2022;23(1):8. doi: 10.1186/s12860-022-00405-w. 

Gershkovich MM, Groß VE, Vu O, Schoeder CT, Meiler J, Prömel S, Kaiser A. Structural Perspective on Ancient Neuropeptide Y-like System reveals Hallmark Features for Peptide Recognition and Receptor Activation. J Mol Biol. 2021;433(13):166992. doi: 10.1016/j.jmb.2021.166992. 

Tang T, Hartig C, Chen Q, Zhao W, Kaiser A, Zhang X, Zhang H, Qu H, Yi C, Ma L, Han S, Zhao Q, Beck-Sickinger AG, Wu B. Structural basis for ligand recognition of the neuropeptide Y Y2 receptor. Nat Commun. 2021;12(1):737. doi: 10.1038/s41467-021-21030-9. 

Ziffert I, Kaiser A, Hoppenz P, Mörl K, Beck-Sickinger AG. Shuttling of Peptide-Drug Conjugates by G Protein-Coupled Receptors Is Significantly Improved by Pulsed Application. ChemMedChem. 2021;16(1):164-178. doi: 10.1002/cmdc.202000490.

Vogel A, Bosse M, Gauglitz M, Wistuba S, Schmidt P, Kaiser A, Gurevich VV, Beck-Sickinger AG, Hildebrand PW, Huster D. The Dynamics of the Neuropeptide Y Receptor Type 1 Investigated by Solid-State NMR and Molecular Dynamics Simulation. Molecules. 2020;25(23):5489. doi: 10.3390/molecules25235489.

Kaiser A, Coin I. Capturing Peptide-GPCR Interactions and Their Dynamics. Molecules. 2020;25(20):4724. doi: 10.3390/molecules25204724. 

Laugwitz JM, Haeri HH, Kaiser A, Krug U, Hinderberger D, Beck-Sickinger AG, Schmidt P. Probing the Y2 Receptor on Transmembrane, Intra- and Extra-Cellular Sites for EPR Measurements. Molecules. 2020;25(18):4143. doi: 10.3390/molecules25184143.

Krug U, Gloge A, Schmidt P, Becker-Baldus J, Bernhard F, Kaiser A, Montag C, Gauglitz M, Vishnivetskiy SA, Gurevich VV, Beck-Sickinger AG, Glaubitz C, Huster D. The Conformational Equilibrium of the Neuropeptide Y2 Receptor in Bilayer Membranes. Angew Chem Int Ed Engl. 2020;59(52):23854-23861. doi: 10.1002/anie.202006075. 

Ziffert I, Kaiser A, Babilon S, Mörl K, Beck-Sickinger AG. Unusually persistent Gαi-signaling of the neuropeptide Y2 receptor depletes cellular Gi/o pools and leads to a Gi-refractory state. Cell Commun Signal. 2020;18(1):49. doi: 10.1186/s12964-020-00537-6. 

Kaiser A, Wanka L, Ziffert I, Beck-Sickinger AG. Biased agonists at the human Y1 receptor lead to prolonged membrane residency and extended receptor G protein interaction. Cell Mol Life Sci. 2020;77(22):4675-4691. doi: 10.1007/s00018-019-03432-7. 

Gershkovich MM, Groß VE, Kaiser A, Prömel S. Pharmacological and functional similarities of the human neuropeptide Y system in C. elegans challenges phylogenetic views on the FLP/NPR system. Cell Commun Signal. 2019;17(1):123. doi: 10.1186/s12964-019-0436-1.

Bech EM, Kaiser A, Bellmann-Sickert K, et al. Half-Life Extending Modifications of Peptide YY3-36 Direct Receptor-Mediated Internalization. Mol Pharm. 2019;16(8):3665-3677. doi:10.1021/acs.molpharmaceut.9b00554

Kögler LM, Stichel J, Kaiser A, Beck-Sickinger AG. Cell-Free Expression and Photo-Crosslinking of the Human Neuropeptide Y2 Receptor. Front Pharmacol. 2019;10:176. doi:10.3389/fphar.2019.00176

Bender BJ, Vortmeier G, Ernicke S, et al. Structural Model of Ghrelin Bound to its G Protein-Coupled Receptor. Structure. 2019;27(3):537-544.e4. doi:10.1016/j.str.2018.12.004

Wanka L, Babilon S, Kaiser A, Mörl K, Beck-Sickinger AG. Different mode of arrestin-3 binding at the human Y1 and Y2 receptor. Cell Signal. 2018;50:58-71. doi:10.1016/j.cellsig.2018.06.010

Yang Z, Han S, Keller M, et al. Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor. Nature. 2018;556(7702):520-524. doi:10.1038/s41586-018-0046-x

Kaiser A, Hempel C, Wanka L, Schubert M, Hamm HE, Beck-Sickinger AG. G Protein Preassembly Rescues Efficacy of W6.48 Toggle Mutations in Neuropeptide Y2 Receptor. Mol Pharmacol. 2018;93(4):387-401. doi:10.1124/mol.117.110544

Schmidt P, Bender BJ, Kaiser A, et al. Improved in Vitro Folding of the Y2 G Protein-Coupled Receptor into Bicelles. Front Mol Biosci. 2018;4:100. doi:10.3389/fmolb.2017.00100

Schmidt P, Bender BJ, Kaiser A, et al. Improved in Vitro Folding of the Y2 G Protein-Coupled Receptor into Bicelles. Front Mol Biosci. 2018;4:100. doi:10.3389/fmolb.2017.00100

Schrottke S, Kaiser A, Vortmeier G, et al. Expression, Functional Characterization, and Solid-State NMR Investigation of the G Protein-Coupled GHS Receptor in Bilayer Membranes. Sci Rep. 2017;7:46128. Published 2017 Apr 7. doi:10.1038/srep46128

Burkert K, Zellmann T, Meier R, et al. A Deep Hydrophobic Binding Cavity is the Main Interaction for Different Y2 R Antagonists. ChemMedChem. 2017;12(1):75-85. doi:10.1002/cmdc.201600433

Burkert K, Zellmann T, Meier R, et al. A Deep Hydrophobic Binding Cavity is the Main Interaction for Different Y2 R Antagonists. ChemMedChem. 2017;12(1):75-85. doi:10.1002/cmdc.201600433

Schönauer R, Kaiser A, Holze C, et al. Fluorescently labeled adrenomedullin allows real-time monitoring of adrenomedullin receptor trafficking in living cells. J Pept Sci. 2015;21(12):905-912. doi:10.1002/psc.2833

Kaiser A, Müller P, Zellmann T, et al. Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y₂ Receptor Binding and Activation. Angew Chem Int Ed Engl. 2015;54(25):7446-7449. doi:10.1002/anie.201411688

Mäde V, Bellmann-Sickert K, Kaiser A, Meiler J, Beck-Sickinger AG. Position and length of fatty acids strongly affect receptor selectivity pattern of human pancreatic polypeptide analogues. ChemMedChem. 2014;9(11):2463-2474. doi:10.1002/cmdc.201402235

Witte K, Kaiser A, Schmidt P, et al. Oxidative in vitro folding of a cysteine deficient variant of the G protein-coupled neuropeptide Y receptor type 2 improves stability at high concentration. Biol Chem. 2013;394(8):1045-1056. doi:10.1515/hsz-2013-0120

Schreiber A, Schramm P, Hofmann HJ. How many hydrogen-bonded α-turns are possible?. J Mol Model. 2011;17(6):1393-1400. doi:10.1007/s00894-010-0830-5